faculty

Stephen Duncan Publications:

Last Updated: December 16, 2016

  1. Mallanna SK, Waas M, Duncan SA, Gundry RL. N-glycoprotein surfaceome of human induced pluripotent stem cell derived hepatic endoderm. Proteomics. 2016, Dec 14 PMID: 27966262
  2. Mallanna SK, Cayo MA, Twaroski K, Gundry RL, Duncan SA. Mapping the Cell-Surface N-Glycoproteome of Human Hepatocytes Reveals Markers for Selecting a Homogeneous Population of iPSC-Derived Hepatocytes. Stem Cell Reports. 2016, Sep 13;7(3):543-56 PMID: 27569060 PMCID: PMC5032032
  3. Duncan SA. Multipotent stem cells and their lineage restriction to hepatocytes. Hepatology. 2016, Oct;64(4):1330. doi: 10.1002/hep.28727 PMID: 27405444
  4. Twaroski K, Mallanna SK, Jing R, DiFurio F, Urick A, Duncan SA. FGF2 mediates hepatic progenitor cell formation during human pluripotent stem cell differentiation by inducing the WNT antagonist NKD1. Genes Dev. 2015 Dec 1;29(23):2463-74. doi: 10.1101/gad.268961.115. PMID: 26637527
  5. Nagaoka M, Kobayashi M, Kawai C, Mallanna SK, Duncan SA. Design of a Vitronectin-Based Recombinant Protein as a Defined Substrate for Differentiation of Human Pluripotent Stem Cells into Hepatocyte-Like Cells. PLoS One. 2015, Aug 26;10(8):e0136350 PMID: 26308339
  6. Yang W, Liu Y, Slovik KJ, Wu JC, Duncan SA, Rader DJ, Morrisey EE. Generation of iPSCs as a Pooled Culture Using Magnetic Activated Cell Sorting of Newly Reprogrammed Cells. PLoS One. 2015, Aug 17;10(8):e0134995 PMID: 26281015
  7. Sall4 overexpression blocks murine hematopoiesis in a dose-dependent manner. (Milanovich S, Peterson J, Allred J, Stelloh C, Rajasekaran K, Fisher J, Duncan SA, Malarkannan S, Rao S) Exp Hematol. 2015 Jan;43(1):53-64. PMID: 25246269 PMCID: PMC4268405
  8. Aneuploidy is permissive for hepatocyte-like cell differentiation from human induced pluripotent stem cells. (Noto FK, Determan MR, Cai J, Cayo MA, Mallanna SK, Duncan SA) BMC Res Notes. 2014 Jul 8;7:437.
  9. Differentiation of hepatocytes from pluripotent stem cells. (Mallanna SK, Duncan SA) Curr Protoc Stem Cell Biol 2013;26:Unit 1G.4. PMID 24510789
  10. Epicardial GATA factors regulate early coronary vascular plexus formation. (Kolander KD, Holtz ML, Cossette SM, Duncan SA, Misra RP) Dev Biol 2014 Feb 1;386(1):204-15 PMID 24380800
  11. Engineering liver tissue from induced pluripotent stem cells: a first step in generating new organs for transplantation? (Fox IJ, Duncan SA) Hepatology 2013 Dec;58(6):2198-201 PMID 24114924
  12. Identification of small molecules for human hepatocyte expansion and iPS differentiation. (Shan J, Schwartz RE, Ross NT, Logan DJ, Thomas D, Duncan SA, North TE, Goessling W, Carpenter AE, Bhatia SN) Nat Chem Biol 2013 Aug;9(8):514-20 PMID 23728495
  13. Pancreas-specific deletion of mouse Gata4 and Gata6 causes pancreatic agenesis. (Xuan S, Borok MJ, Decker KJ, Battle MA, Duncan SA, Hale MA, Macdonald RJ, Sussel L) J Clin Invest 2012 Oct;122(10):3516-28 PMID 23006325
  14. Hepatocyte-like cells differentiated from human induced pluripotent stem cells: relevance to cellular therapies. (Yu Y, Liu H, Ikeda Y, Amiot BP, Rinaldo P, Duncan SA, Nyberg SL) Stem Cell Res 2012 Nov;9(3):196-207 PMID 22885101
  15. Comparison of cardiomyogenic potential among human ESC and iPSC lines. (Sepac A, Si-Tayeb K, Sedlic F, Barrett S, Canfield S, Duncan SA, Bosnjak ZJ, Lough JW) Cell Transplant 2012;21(11):2523-30 PMID 22863088
  16. JD induced pluripotent stem cell-derived hepatocytes faithfully recapitulate the pathophysiology of familial hypercholesterolemia. (Cayo MA, Cai J, DeLaForest A, Noto FK, Nagaoka M, Clark BS, Collery RF, Si-Tayeb K, Duncan SA) Hepatology 2012 Dec;56(6):2163-71 PMID 22653811
  17. A cell surfaceome map for immunophenotyping and sorting pluripotent stem cells. (Gundry RL, Riordon DR, Tarasova Y, Chuppa S, Bhattacharya S, Juhasz O, Wiedemeier O, Milanovich S, Noto FK, Tchernyshyov I, Raginski K, Bausch-Fluck D, Tae HJ, Marshall S, Duncan SA, Wollscheid B, Wersto RP, Rao S, Van Eyk JE, Boheler KR) Mol Cell Proteomics 2012 Aug;11(8):303-16 PMID 22493178
  18. Modeling hepatitis C virus infection using human induced pluripotent stem cells. (Schwartz RE, Trehan K, Andrus L, Sheahan TP, Ploss A, Duncan SA, Rice CM, Bhatia SN) Proc Natl Acad Sci U S A 2012 Feb 14;109(7):2544-8 PMID 22308485
  19. Endoplasmic reticulum-tethered transcription factor cAMP responsive element-binding protein, hepatocyte specific, regulates hepatic lipogenesis, fatty acid oxidation, and lipolysis upon metabolic stress in mice. (Zhang C, Wang G, Zheng Z, Maddipati KR, Zhang X, Dyson G, Williams P, Duncan SA, Kaufman RJ, Zhang K) Hepatology 2012 Apr;55(4):1070-82 PMID 22095841
  20. HNF4A is essential for specification of hepatic progenitors from human pluripotent stem cells. (DeLaForest A, Nagaoka M, Si-Tayeb K, Noto FK, Konopka G, Battle MA, Duncan SA) Development 2011 Oct;138(19):4143-53 PMID 21852396
  21. The transcription factor cyclic AMP-responsive element-binding protein H regulates triglyceride metabolism. (Lee JH, Giannikopoulos P, Duncan SA, Wang J, Johansen CT, Brown JD, Plutzky J, Hegele RA, Glimcher LH, Lee AH) Nat Med 2011 Jul;17(7):812-5 PMID 21666694
  22. Induction of cardiomyogenesis in human embryonic stem cells by human embryonic stem cell-derived definitive endoderm. (Van Orman JR, Si-Tayeb K, Duncan SA, Lough J) Stem Cells Dev 2012 Apr 10;21(6):987-94 PMID 21627569
  23. GATA factors regulate proliferation, differentiation, and gene expression in small intestine of mature mice. (Beuling E, Baffour-Awuah NY, Stapleton KA, Aronson BE, Noah TK, Shroyer NF, Duncan SA, Fleet JC, Krasinski SD) Gastroenterology 2011 Apr;140(4):1219-1229.e1-2 PMID 21262227
  24. Transcriptional control of hepatocyte differentiation. (Nagaoka M, Duncan SA) Prog Mol Biol Transl Sci 2010;97:79-101 PMID 21074730
  25. Isoflurane preconditioning elicits competent endogenous mechanisms of protection from oxidative stress in cardiomyocytes derived from human embryonic stem cells. (Sepac A, Sedlic F, Si-Tayeb K, Lough J, Duncan SA, Bienengraeber M, Park F, Kim J, Bosnjak ZJ) Anesthesiology 2010 Oct;113(4):906-16 PMID 20823757
  26. The transcription factor GATA-6 regulates pathological cardiac hypertrophy. (van Berlo JH, Elrod JW, van den Hoogenhof MM, York AJ, Aronow BJ, Duncan SA, Molkentin JD) Circ Res 2010 Oct 15;107(8):1032-40 PMID 20705924
  27. Generation of human induced pluripotent stem cells by simple transient transfection of plasmid DNA encoding reprogramming factors. (Si-Tayeb K, Noto FK, Sepac A, Sedlic F, Bosnjak ZJ, Lough JW, Duncan SA) BMC Dev Biol 2010;10:81 PMID 20682060
  28. Culture of human pluripotent stem cells using completely defined conditions on a recombinant E-cadherin substratum. (Nagaoka M, Si-Tayeb K, Akaike T, Duncan SA) BMC Dev Biol 2010;10:60 PMID 20525219
  29. Foxa1 functions as a pioneer transcription factor at transposable elements to activate Afp during differentiation of embryonic stem cells. (Taube JH, Allton K, Duncan SA, Shen L, Barton MC) J Biol Chem 2010 May 21;285(21):16135-44 PMID 20348100
  30. Organogenesis and development of the liver. (Si-Tayeb K, Lemaigre FP, Duncan SA) Dev Cell 2010 Feb 16;18(2):175-89 PMID 20159590
  31. Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells. (Si-Tayeb K, Noto FK, Nagaoka M, Li J, Battle MA, Duris C, North PE, Dalton S, Duncan SA) Hepatology 2010 Jan;51(1):297-305 PMID 19998274
  32. ER stress controls iron metabolism through induction of hepcidin. (Vecchi C, Montosi G, Zhang K, Lamberti I, Duncan SA, Kaufman RJ, Pietrangelo A) Science 2009 Aug 14;325(5942):877-80 PMID 19679815
  33. Hepatocyte expression of serum response factor is essential for liver function, hepatocyte proliferation and survival, and postnatal body growth in mice. (Sun K, Battle MA, Misra RP, Duncan SA) Hepatology 2009 May;49(5):1645-54 PMID 19205030
  34. GATA4 is essential for jejunal function in mice. (Battle MA, Bondow BJ, Iverson MA, Adams SJ, Jandacek RJ, Tso P, Duncan SA) Gastroenterology 2008 Nov;135(5):1676-1686.e1 PMID 18812176
  35. Hepatocyte nuclear factor 4alpha is implicated in endoplasmic reticulum stress-induced acute phase response by regulating expression of cyclic adenosine monophosphate responsive element binding protein H. (Luebke-Wheeler J, Zhang K, Battle M, Si-Tayeb K, Garrison W, Chhinder S, Li J, Kaufman RJ, Duncan SA) Hepatology 2008 Oct;48(4):1242-50 PMID 18704925
  36. Design of the artificial acellular feeder layer for the efficient propagation of mouse embryonic stem cells. (Nagaoka M, Hagiwara Y, Takemura K, Murakami Y, Li J, Duncan SA, Akaike T) J Biol Chem 2008 Sep 26;283(39):26468-76 PMID 18614540
  37. Loss of both GATA4 and GATA6 blocks cardiac myocyte differentiation and results in acardia in mice. (Zhao R, Watt AJ, Battle MA, Li J, Bondow BJ, Duncan SA) Dev Biol 2008 May 15;317(2):614-9 PMID 18400219
  38. Cardiomyocyte GATA4 functions as a stress-responsive regulator of angiogenesis in the murine heart. (Heineke J, Auger-Messier M, Xu J, Oka T, Sargent MA, York A, Klevitsky R, Vaikunth S, Duncan SA, Aronow BJ, Robbins J, Crombleholme TM, Molkentin JD) J Clin Invest 2007 Nov;117(11):3198-210 PMID 17975667
  39. Cited2, a coactivator of HNF4alpha, is essential for liver development. (Qu X, Lam E, Doughman YQ, Chen Y, Chou YT, Lam M, Turakhia M, Dunwoodie SL, Watanabe M, Xu B, Duncan SA, Yang YC) EMBO J 2007 Oct 31;26(21):4445-56 PMID 17932483
  40. Junctional adhesion molecule-A is critical for the formation of pseudocanaliculi and modulates E-cadherin expression in hepatic cells. (Konopka G, Tekiela J, Iverson M, Wells C, Duncan SA) J Biol Chem 2007 Sep 21;282(38):28137-48 PMID 17623668
  41. Development of the mammalian liver and ventral pancreas is dependent on GATA4. (Watt AJ, Zhao R, Li J, Duncan SA) BMC Dev Biol 2007;7:37 PMID 17451603
  42. Light chain 1 of microtubule-associated protein 1B can negatively regulate the action of Pes1. (Lerch-Gaggl AF, Sun K, Duncan SA) J Biol Chem 2007 Apr 13;282(15):11308-16 PMID 17308336
  43. Essential function of PTP-PEST during mouse embryonic vascularization, mesenchyme formation, neurogenesis and early liver development. (Sirois J, Côté JF, Charest A, Uetani N, Bourdeau A, Duncan SA, Daniels E, Tremblay ML) Mech Dev 2006 Dec;123(12):869-80 PMID 17070019
  44. Improved cardiac function in infarcted mice after treatment with pluripotent embryonic stem cells. (Nelson TJ, Ge ZD, Van Orman J, Barron M, Rudy-Reil D, Hacker TA, Misra R, Duncan SA, Auchampach JA, Lough JW) Anat Rec A Discov Mol Cell Evol Biol 2006 Nov;288(11):1216-24 PMID 17004246
  45. A threshold of GATA4 and GATA6 expression is required for cardiovascular development. (Xin M, Davis CA, Molkentin JD, Lien CL, Duncan SA, Richardson JA, Olson EN) Proc Natl Acad Sci U S A 2006 Jul 25;103(30):11189-94 PMID 16847256
  46. Hepatocyte nuclear factor 4alpha orchestrates expression of cell adhesion proteins during the epithelial transformation of the developing liver. (Battle MA, Konopka G, Parviz F, Gaggl AL, Yang C, Sladek FM, Duncan SA) Proc Natl Acad Sci U S A 2006 May 30;103(22):8419-24 PMID 16714383
  47. Hepatocyte nuclear factor 4alpha is essential for embryonic development of the mouse colon. (Garrison WD, Battle MA, Yang C, Kaestner KH, Sladek FM, Duncan SA) Gastroenterology 2006 Apr;130(4):1207-20 PMID 16618389
  48. Generation of mice harbouring a conditional loss-of-function allele of Gata6. (Sodhi CP, Li J, Duncan SA) BMC Dev Biol 2006;6:19 PMID 16611361
  49. Transcriptional regulation of the human hepatic lipase (LIPC) gene promoter. (Rufibach LE, Duncan SA, Battle M, Deeb SS) J Lipid Res 2006 Jul;47(7):1463-77 PMID 16603721
  50. Cardiac-specific deletion of Gata4 reveals its requirement for hypertrophy, compensation, and myocyte viability. (Oka T, Maillet M, Watt AJ, Schwartz RJ, Aronow BJ, Duncan SA, Molkentin JD) Circ Res 2006 Mar 31;98(6):837-45 PMID 16514068
  51. Generation of embryos directly from embryonic stem cells by tetraploid embryo complementation reveals a role for GATA factors in organogenesis. (Duncan SA) Biochem Soc Trans 2005 Dec;33(Pt 6):1534-6 PMID 16246163
  52. Embryonic development of the liver. (Zhao R, Duncan SA) Hepatology 2005 May;41(5):956-67 PMID 15841465
  53. GATA6 is essential for embryonic development of the liver but dispensable for early heart formation. (Zhao R, Watt AJ, Li J, Luebke-Wheeler J, Morrisey EE, Duncan SA) Mol Cell Biol 2005 Apr;25(7):2622-31 PMID 15767668
  54. Retinoic acid, hypoxia, and GATA factors cooperatively control the onset of fetal liver erythropoietin expression and erythropoietic differentiation. (Makita T, Duncan SA, Sucov HM) Dev Biol 2005 Apr 1;280(1):59-72 PMID 15766748
  55. The MODY1 gene HNF-4alpha regulates selected genes involved in insulin secretion. (Gupta RK, Vatamaniuk MZ, Lee CS, Flaschen RC, Fulmer JT, Matschinsky FM, Duncan SA, Kaestner KH) J Clin Invest 2005 Apr;115(4):1006-15 PMID 15761495
  56. GATA4 is essential for formation of the proepicardium and regulates cardiogenesis. (Watt AJ, Battle MA, Li J, Duncan SA) Proc Natl Acad Sci U S A 2004 Aug 24;101(34):12573-8 PMID 15310850
  57. Progression of HCC in mice is associated with a downregulation in the expression of hepatocyte nuclear factors. (Lazarevich NL, Cheremnova OA, Varga EV, Ovchinnikov DA, Kudrjavtseva EI, Morozova OV, Fleishman DI, Engelhardt NV, Duncan SA) Hepatology 2004 Apr;39(4):1038-47 PMID 15057908
  58. Conserved enhancer in the serum response factor promoter controls expression during early coronary vasculogenesis. (Nelson TJ, Duncan SA, Misra RP) Circ Res 2004 Apr 30;94(8):1059-66 PMID 15001533
  59. Hepatocyte nuclear factor 4alpha controls the development of a hepatic epithelium and liver morphogenesis. (Parviz F, Matullo C, Garrison WD, Savatski L, Adamson JW, Ning G, Kaestner KH, Rossi JM, Zaret KS, Duncan SA) Nat Genet 2003 Jul;34(3):292-6 PMID 12808453
  60. HNF4: a central regulator of hepatocyte differentiation and function. (Watt AJ, Garrison WD, Duncan SA) Hepatology 2003 Jun;37(6):1249-53 PMID 12774000
  61. Gene targeting in the mouse: advances in introduction of transgenes into the genome by homologous recombination. (Misra RP, Duncan SA) Endocrine 2002 Dec;19(3):229-38 PMID 12624422
  62. The orphan nuclear receptor HNF4alpha determines PXR- and CAR-mediated xenobiotic induction of CYP3A4. (Tirona RG, Lee W, Leake BF, Lan LB, Cline CB, Lamba V, Parviz F, Duncan SA, Inoue Y, Gonzalez FJ, Schuetz EG, Kim RB) Nat Med 2003 Feb;9(2):220-4 PMID 12514743
  63. Mechanisms controlling early development of the liver. (Duncan SA) Mech Dev 2003 Jan;120(1):19-33 PMID 12490293
  64. Pescadillo is essential for nucleolar assembly, ribosome biogenesis, and mammalian cell proliferation. (Lerch-Gaggl A, Haque J, Li J, Ning G, Traktman P, Duncan SA) J Biol Chem 2002 Nov 22;277(47):45347-55 PMID 12237316
  65. Generation of a conditionally null allele of hnf4alpha. (Parviz F, Li J, Kaestner KH, Duncan SA) Genesis 2002 Feb;32(2):130-3 PMID 11857799
  66. Generation of single-copy transgenic mouse embryos directly from ES cells by tetraploid embryo complementation. (Misra RP, Bronson SK, Xiao Q, Garrison W, Li J, Zhao R, Duncan SA) BMC Biotechnol 2001;1:12 PMID 11782291
  67. BMPs on the road to hepatogenesis. (Duncan SA, Watt AJ) Genes Dev 2001 Aug 1;15(15):1879-84 PMID 11485983
  68. An efficient method to successively introduce transgenes into a given genomic locus in the mouse. (Zhao R, Fahs SA, Weiler H, Duncan SA) BMC Dev Biol 2001;1:10 PMID 11430765
  69. The pancreas and its heartless beginnings. (Duncan SA) Nat Genet 2001 Apr;27(4):355-6 PMID 11279510
  70. The murine Pes1 gene encodes a nuclear protein containing a BRCT domain. (Haque J, Boger S, Li J, Duncan SA) Genomics 2000 Dec 1;70(2):201-10 PMID 11112348
  71. Transcriptional regulation of liver development. (Duncan SA) Dev Dyn 2000 Oct;219(2):131-42 PMID 11002334
  72. Mammalian hepatocyte differentiation requires the transcription factor HNF-4alpha. (Li J, Ning G, Duncan SA) Genes Dev 2000 Feb 15;14(4):464-74 PMID 10691738
  73. Impaired glucose homeostasis and neonatal mortality in hepatocyte nuclear factor 3alpha-deficient mice. (Shih DQ, Navas MA, Kuwajima S, Duncan SA, Stoffel M) Proc Natl Acad Sci U S A 1999 Aug 31;96(18):10152-7 PMID 10468578
  74. The vaccinia virus A4OR gene product is a nonstructural, type II membrane glycoprotein that is expressed at the cell surface. (Wilcock D, Duncan SA, Traktman P, Zhang WH, Smith GL) J Gen Virol 1999 Aug;80 ( Pt 8):2137-48 PMID 10466813
  75. In situ hybridization with 33P-labeled RNA probes for determination of cellular expression patterns of liver transcription factors in mouse embryos. (Rausa FM, Ye H, Lim L, Duncan SA, Costa RH) Methods 1998 Sep;16(1):29-41 PMID 9774514
  76. Regulation of a transcription factor network required for differentiation and metabolism. (Duncan SA, Navas MA, Dufort D, Rossant J, Stoffel M) Science 1998 Jul 31;281(5377):692-5 PMID 9685261
  77. The maturity-onset diabetes of the young (MODY1) transcription factor HNF4alpha regulates expression of genes required for glucose transport and metabolism. (Stoffel M, Duncan SA) Proc Natl Acad Sci U S A 1997 Nov 25;94(24):13209-14 PMID 9371825
  78. Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis. (Molkentin JD, Lin Q, Duncan SA, Olson EN) Genes Dev 1997 Apr 15;11(8):1061-72 PMID 9136933
  79. Normal cerebellar development but susceptibility to seizures in mice lacking G protein-coupled, inwardly rectifying K+ channel GIRK2. (Signorini S, Liao YJ, Duncan SA, Jan LY, Stoffel M) Proc Natl Acad Sci U S A 1997 Feb 4;94(3):923-7 PMID 9023358
  80. STAT signaling is active during early mammalian development. (Duncan SA, Zhong Z, Wen Z, Darnell JE Jr) Dev Dyn 1997 Feb;208(2):190-8 PMID 9022056
  81. Murine gastrulation requires HNF-4 regulated gene expression in the visceral endoderm: tetraploid rescue of Hnf-4(-/-) embryos. (Duncan SA, Nagy A, Chan W) Development 1997 Jan;124(2):279-87 PMID 9053305
  82. Disruption of the MacMARCKS gene prevents cranial neural tube closure and results in anencephaly. (Chen J, Chang S, Duncan SA, Okano HJ, Fishell G, Aderem A) Proc Natl Acad Sci U S A 1996 Jun 25;93(13):6275-9 PMID 8692805
  83. Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos. (Chen WS, Manova K, Weinstein DC, Duncan SA, Plump AS, Prezioso VR, Bachvarova RF, Darnell JE Jr) Genes Dev 1994 Oct 15;8(20):2466-77 PMID 7958910
  84. Expression of transcription factor HNF-4 in the extraembryonic endoderm, gut, and nephrogenic tissue of the developing mouse embryo: HNF-4 is a marker for primary endoderm in the implanting blastocyst. (Duncan SA, Manova K, Chen WS, Hoodless P, Weinstein DC, Bachvarova RF, Darnell JE Jr) Proc Natl Acad Sci U S A 1994 Aug 2;91(16):7598-602 PMID 8052626
  85. Vaccinia virus gene SalF5R is non-essential for virus replication in vitro and in vivo. (Duncan SA, Smith GL) J Gen Virol 1992 May;73 ( Pt 5):1235-42 PMID 1588324
  86. Identification and characterization of an extracellular envelope glycoprotein affecting vaccinia virus egress. (Duncan SA, Smith GL) J Virol 1992 Mar;66(3):1610-21 PMID 1738204
  87. Vaccinia DNA ligase complements Saccharomyces cerevisiae cdc9, localizes in cytoplasmic factories and affects virulence and virus sensitivity to DNA damaging agents. (Kerr SM, Johnston LH, Odell M, Duncan SA, Law KM, Smith GL) EMBO J 1991 Dec;10(13):4343-50 PMID 1756739

 

Last updated on 16-Dec-2016
 
 

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