Department of Regenerative Medicine and Cell biology

Sibnath Ghatak

Sibnath Ghatak, Ph.D.
Assistant Professor
Member of Hollings Cancer Center


Room 613, Basic Science Building
Office: (843) 792-8642


Email: ghatak@musc.edu

Ghatak CV


Education:

PhD Calcutta Univ. (India), 1977
MA Univ. of Massachusetts, 2004

Research Interests:

To investigate the role of:

  1. Hyaluronan-CD44 interaction in regulation of ERBB2 and IGF1R signaling and androgen receptor-mediated activity such as PSA production, hK2 glandular kellikrein2 in prostate cancer cells.
  2. Hyaluronan signaling in endothelial cell transformation in the ductus arteriosus (DA) development and closure.
  3. Hyaluronan signaling in the smooth muscle cell activation in various stages of atherosclerosis.

Recent Publications:

  1. Kolpa, H. J., D. S. Peal, S. N. Lynch, A. C. Giokas, S. Ghatak, S. Misra, R. A. Norris, C. A. Macrae, R. R. Markwald, P. Ellinor, J. Bischoff and D. J. Milan. "Mir-21 Represses Pdcd4 During Cardiac Valvulogenesis." Development 140, no. 10 (2013): 2172-80.
  2. Misra, S., S. Ghatak, N. Patil, P. Dandawate, V. Ambike, S. Adsule, D. Unni, K. Venkateswara Swamy and S. Padhye. "Novel Dual Cyclooxygenase and Lipoxygenase Inhibitors Targeting Hyaluronan-Cd44v6 Pathway and Inducing Cytotoxicity in Colon Cancer Cells." Bioorg Med Chem 21, no. 9 (2013): 2551-9.
  3. Misra S, Heldin P, Hascall VC, Karamanos NK, Skandalis SS, Markwald RR, Ghatak S. Hyaluronan-CD44 interactions as potential targets for cancer therapy.  FEBS J. 2011 May;278(9):1429-43. doi: 10.1111/j.1742-4658.2011.08071.x. Epub 2011 Mar 25. Review.
  4. Ghatak S, Hascall VC, Markwald RR, Misra S. Stromal hyaluronan interaction with epithelial CD44 variants promotes prostate cancer invasiveness by augmenting expression and function of hepatocyte growth factor and androgen receptor.  J Biol Chem. 2010 Jun 25;285(26):19821-32. Epub 2010 Mar 3.
  5. Misra S, Hascall VC, De Giovanni C, Markwald RR, Ghatak S. Delivery of CD44 shRNA/nanoparticles within cancer cells: perturbation of hyaluronan/CD44v6 interactions and reduction in adenoma growth in Apc Min/+ MICE.  J Biol Chem. 2009 May 1;284(18):12432-46. Epub 2009 Feb 26.
  6. Toole BP, Ghatak S, Misra S. Hyaluronan oligosaccharides as a potential anticancer therapeutic.  Curr Pharm Biotechnol. 2008 Aug;9(4):249-52.
  7. Ghatak S, Hascall VC, Berger FG, Penas MM, Davis C, Jabari E, He X, Norris JS, Dang Y, Markwald RR, Misra S. Tissue-specific shRNA delivery: a novel approach for gene therapy in cancer.  Connect Tissue Res. 2008;49(3):265-9.
  8. Misra S, Hascall VC, Berger FG, Markwald RR, Ghatak S. Hyaluronan, CD44, and cyclooxygenase-2 in colon cancer.  Connect Tissue Res. 2008;49(3):219-24. Review.
  9. Misra S, Obeid LM, Hannun YA, Minamisawa S, Berger FG, Markwald RR, Toole BP, Ghatak S. Hyaluronan constitutively regulates activation of COX-2-mediated cell survival activity in intestinal epithelial and colon carcinoma cells.  J Biol Chem. 2008 May 23;283(21):14335-44. Epub 2008 Mar 7.
  10. Yokoyama U, Minamisawa S, Quan H, Ghatak S, Akaike T, Segi-Nishida E, Iwasaki S, Iwamoto M, Misra S, Tamura K, Hori H, Yokota S, Toole BP, Sugimoto Y, Ishikawa Y. Chronic activation of the prostaglandin receptor EP4 promotes hyaluronan-mediated neointimal formation in the ductus arteriosus.  J Clin Invest. 2006;116:3026-3034.
  11. Misra S, Toole BP, Ghatak S. Hyaluronan constitutively regulates activation of multiple receptor tyrosine kinases in epithelial and carcinoma cells.  J Biol Chem. 2006 Nov 17;281(46):34936-41.
  12. Toole BP, Zoltan-Jones A, Misra S, Ghatak S. Hyaluronan: a critical component of epithelial-mesenchymal and epithelial-carcinoma transitions.  Cells Tissues Organs. 2005;179:66-72.
  13. Misra S, Ghatak S, Toole BP. Regulation of MDR1 expression and drug resistance by a positive feedback loop involving hyaluronan, phosphoinositide 3-kinase, and ErbB2.  J Biol Chem. 2005;280:20310-5.
  14. Ghatak S, Toole BP, Misra S. Hyaluronan constitutively regulates ErbB2 phosphorylation and signaling complex formation in carcinoma cells.  J Biol Chem. 2005; 280:8875-83.
  15. Marieb EA, Zoltan-Jones A, Li R, Misra S, Ghatak S, Cao J, Zucker S, Toole BP. Emmprin promotes anchorage-independent growth in human mammary carcinoma cells by stimulating hyaluronan production.  Cancer Res. 2004;64:1229-32.
  16. Misra S, Ghatak S, Zoltan-Jones A, Toole BP. Regulation of multidrug resistance in cancer cells by hyaluronan.  J Biol Chem. 2003;278:25285-8.
  17. Zoltan-Jones A, Huang L, Ghatak S, Toole BP. Elevated hyaluronan production induces mesenchymal and transformed properties in epithelial cells.  J Biol Chem. 2003;278:45801-10.
  18. Ghatak S, Misra S, Toole BP. Hyaluronan oligosaccharides inhibit anchorage-independent growth of tumor cells by suppressing the phosphoinositide 3-kinase/Akt cell survival pathway.  J Biol Chem. 2002; 277:38013-20.
  19. Ward JA, Huang L, Guo H, Ghatak S, Toole BP. Am J Pathol. 2003;162:1403-9.

 

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