Department of Regenerative Medicine and Cell biology

morad

Martin Morad, Ph.D.
Professor

BlueCross BlueShield of South Carolina Foundation Endowed Chair in Cardiovascular Health at USC

Room 319B
Office: (843) 792-3898

Email: moradm@musc.edu

Education:

BA Lake Forest College 1961
PhD Physiology SUNY, New York City 1965
Postdoctoral work at Heidelberg University and UCLA

Dr. Morad is an internationally recognized scientist in the field of cardiac electrophysiology and calcium signaling, specifically in the area of calcium-binding proteins. The cardiac muscle is a complex system composed of 40,000 proteins. These proteins "tell" the heart how to contract and how fast; they also control how heart muscle grows and regenerates. Calcium acts as a signaling mechanism in the function of these proteins. Dr. Morad seeks to discover what causes these calcium signaling mechanisms to stop working properly, which can result in congestive heart failure. Understanding this process could lead to new therapeutic approaches to treat congestive heart failure and other conditions. His work could lead to the world's first tissue-derived human heart pacemaker. A biological pacemaker derived from genetically engineered cells has great commercial viability as a replacement for current pacemaker technology made from artificial materials

Selected Publications:

  1. Arnaiz-Cot, J. J., B. J. Damon, X. H. Zhang, L. Cleemann, N. Yamaguchi, G. W. Meissner and M. Morad. "Cardiac Calcium Signaling Pathologies Associated with Defective Calmodulin Regulation of Type 2 Ryanodine Receptor." J Physiol, (2013) [PMID: 23836685]
  2. Rosa, A. O., N. Yamaguchi and M. Morad. "Mechanical Regulation of Native and the Recombinant Calcium Channel." Cell Calcium 53, no. 4 (2013): 264-74 [PMID: 23357406]
  3. Sonbol, M. B., B. Firwana, A. Zarzour, M. Morad, V. Rana and R. V. Tiu. "Comprehensive Review of Jak Inhibitors in Myeloproliferative Neoplasms." Ther Adv Hematol 4, no. 1 (2013): 15-35 [PMID: 23610611]
  4. Zhang, X. H., S. Haviland, H. Wei, T. Saric, A. Fatima, J. Hescheler, L. Cleemann and M. Morad. "Ca2+ Signaling in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes (Ips-Cm) from Normal and Catecholaminergic Polymorphic Ventricular Tachycardia (Cpvt)-Afflicted Subjects." Cell Calcium 54, no. 2 (2013): 57-70 [PMID: 23684427]
  5. Kohl, P., C. Bollensdorff and M. Morad. "Progress in Biophysics and Molecular Biology of the Beating Heart." Prog Biophys Mol Biol 110, no. 2-3 (2012): 151-3 [PMID: 22947419]
  6. Rosa, A. O., S. Movafagh, L. Cleemann and M. Morad. "Hypoxic Regulation of Cardiac Ca2+ Channel: Possible Role of Haem Oxygenase." J Physiol 590, no. Pt 17 (2012): 4223-37 [PMID: 22753548]
  7. Sankar, M., Q. He, M. Morad, J. Pritchard, S. J. Freakley, J. K. Edwards, S. H. Taylor, D. J. Morgan, A. F. Carley, D. W. Knight, C. J. Kiely and G. J. Hutchings. "Synthesis of Stable Ligand-Free Gold-Palladium Nanoparticles Using a Simple Excess Anion Method." ACS Nano 6, no. 8 (2012): 6600-13 [PMID: 22769042]
  8. Tufan, H., X. H. Zhang, N. Haghshenas, M. A. Sussman, L. Cleemann and M. Morad. "Cardiac Progenitor Cells Engineered with Pim-1 (Cpcep) Develop Cardiac Phenotypic Electrophysiological Properties as They Are Co-Cultured with Neonatal Myocytes." J Mol Cell Cardiol 53, no. 5 (2012): 695-706 [PMID: 23010478]
  9. Belmonte S, Morad M. "Pressure-flow"-triggered Cai-transients in rat cardiac myocytes: possible mechanisms and role of mitochondria. J Physiol. [Epub ahead of print] 2008
  10. Janowski E, Cleemann L, Sasse P, Morad M. Diversity of Ca2+ signaling in developing cardiac cells. Ann N Y Acad Sci.1080:154-64. 2006
  11. N'Gouemo P, Yasuda RP, Morad M. Ethanol withdrawal is accompanied by downregulation of calcium channel alpha 1B subunit in rat inferior colliculus neurons. Brain Res. 1108(1):216-20. 2006
  12. Morad M, Soldatov N: Calcium channel inactivation: possible role in signal transduction and Ca2+ signaling. Cell Calcium. 38:223-231, 2005
  13. Morad M, Javaheri A, Risius T, Belmonte S: Multimodality of Ca2+ signaling in rat atrial myocytes. Ann N Y Acad Sci. 1047:112-121, 2005
  14. Woo SH, Cleemann L, Morad M: Diversity of atrial local Ca2+ signalling: evidence from 2-D confocal imaging in Ca2+-buffered rat atrial myocytes. J Physiol. 567:905-921, 2005
  15. Morad M, Cleemann L, Knollmann BC:  Triadin: the new player on excitation-contraction coupling block. Circ Res. 96:607-9, 2005
  16. Abdrakhmanova G, Cleemann L, Lindstrom J, Morad M.Differential modulation of beta2 and beta4 subunits of human neuronal nicotinic acetylcholine receptors by acidification. Mol Pharmacol. 66:347-55, 2004
  17. Morad M, Chau M. Learning about cardiac calcium signaling from genetic engineering. Ann N Y Acad Sci. 1015:1-15, 2004
  18. Woo SH, Soldatov NM, Morad M. Modulation of Ca2+ signalling in rat atrial myocytes: possible role of the alpha1C carboxyl terminal. J Physiol. 552:437-47, 2003
  19. N'Gouemo P, Morad M. Voltage-gated calcium channels in adult rat inferior colliculus neurons. Neurosci. 120:815-826, 2003
  20. N'Gouemo P, Morad M. Ethanol withdrawal seizure susceptibility is associated with upregulation of L- and P-type Ca2+ channel currents in rat inferior colliculus neurons. Neuropharmacology. 429-437,2003
  21. He LP, Cleemann L, Soldatov NM, Morad M. Molecular determinants of cAMP-mediated regulation of the Na+-Ca2+ exchanger expressed in human cell lines. J Physiol. 548:677-689, 2003
  22. Knollmann BC, Kirchhof P, Sirenko SG, Degen H, Greene AE, Schober T, Mackow JC, Fabritz L, Potter JD, Morad M. Familial hypertrophic cardiomyopathy-linked mutant troponin T causes stress-induced ventricular tachycardia and Ca2+-dependent action potential remodeling. Circ Res. 92:428-436, 2003
  23. Woo SH, Cleemann L, Morad M. Spatiotemporal characteristics of junctional and nonjunctional focal Ca2+ release in rat atrial myocytes. Circ Res. 92:1-11, 2003
  24. Woo SH, Cleemann L, Morad M. Ca(2+) current-gated focal and local Ca(2+) release in rat atrial myocytes: evidence from rapid 2-D confocal imaging. J Physiol. 543:439-453, 2002
  25. Abdrakhmanova G, Dorfman J, Xiao Y, Morad M. Protons enhance the gating kinetics of the alpha3/beta4 neuronal nicotinic acetylcholine receptor by increasing its apparent affinity to agonists. Mol Pharmacol. 61:369-378, 2002
  26. Woo SH, Morad M. Bimodal regulation of Na+-Ca2+ exchanger by beta -adrenergic signaling pathway in shark ventricular myocytes. Proc Natl Acad Sci U S A. 98:2023-2028, 2001
  27. Knollmann BC, Blatt SA, Horton K, de Freitas F, Miller T, Bell M, Housmans PR, Weissman NJ, Morad M, Potter JD. Inotropic stimulation induces cardiac dysfunction in transgenic mice expressing a troponin T (I79N) mutation linked to familial hypertrophic cardiomyopathy. J Biol Chem. 276:10039-10048, 2001
  28. Morad M, Suzuki YJ. Redox regulation of cardiac muscle calcium signaling. Antioxid Redox Signal. 2:65-71, 2000
  29. Soldatov NM, Zhenochin S, AlBanna B, Abernethy DR, Morad M. New molecular determinant for inactivation of the human L-type alpha(1C) Ca(2+) channel. J Membr Biol. 177:129-135, 2000

 

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