Russell A. Norris, Ph.D.
Room 608, Children's
Office: (843) 792-1544
University of Cincinnati 1991-1995 Bachelors of Science (Biology)
Medical University of South Carolina 1995-2000 PhD (Molecular, Cellular and Pathobiology)
Medical University of South Carolina 2001-2006 Post Doctoral Research
Medical University of South Carolina 2007-Current Assistant Professor
A primary focus of the Norris lab is to deal with basic questions in formation of the cardiac valves and pathological processes that result in valve disease. The overall design follows a “cycle of discovery” that begins with the clinical condition, identifies gene candidates, and explores their mechanism of action. These mechanistic studies, in turn, point to related pathways for further gene discovery. Through an international consortium of clinicians and scientists, our group has identified genetic and biological causes for common cardiac disease, e.g. mitral valve prolapse and bicuspid aortic valve disease. Our ongoing projects have defined that these genes play a crucial role during the development of the valves, essentially laying the blueprint for valve construction. Thus, inherited heart valve disease is caused by inborn errors in the development of this structure. By studying these disease genes we can gain an understanding for how the valve develops and why valve defects occur. Harnessed with this information, targeted therapeutics can be developed that may be of benefit to patients with valvular heart disease, thus allowing us to complete the “cycle of discovery”.
Select Recent Publications:
- Norris RA and Kern MJ. Functional characterization of domains important for transcriptional regulation by Prx1 and Prx2 homeoproteins. Molecular Biology of the Cell 10S:p96:556 1999
- Norris RA, Scott KK, Moore CS, Stetten G, Brown CR, Jabs EW, Wulfsberg EA,Yu J, and Kern MJ. Human PRRX1 and PRRX2 genes: cloning, expression, genomic localization, and exclusion as disease genes for Nager syndrome. Mammalian Genome 11:1000-1005, 2000
- Norris RA and Kern MJ. Identification of domains mediating transcription activation, repression, and inhibition in the paired-related homeobox protein, Prx2 (S8). DNA Cell Biol. 2001 Feb;20(2):89-99.
- Norris, RA and Kern MJ. The identification of Prx1 transcription regulatory domains provides a mechanism for unequal compensation by the Prx1 and Prx2 loci. J Biol Chem. 2001 Jul 20;276(29):26829-37. Epub 2001 May 23.
- Mjaatvedt CH, Nakaoka T, Moreno-Rodriguez R, Norris RA, Kern MJ, Eisenberg CA, Turner D, Markwald RR. The outflow tract of the heart is recruited from a novel heart-forming field. Dev Biol. 2001 Oct 1;238(1):97-109.
- Scott KK, Norris RA, Potter SS, Norrington DW, Baybo MA, Hicklin DM, Kern MJ. GeneChip microarrays facilitate identification of Protease Nexin-1 as a target gene of the Prx2 (S8) homeoprotein. DNA Cell Biol. 2003 Feb;22(2):95-105
- Norris RA, Kern CB, Wessels A, Moralez EI, Markwald RR, Mjaatvedt CH. Identification and detection of the periostin gene in cardiac development. Anat Rec A Discov Mol Cell Evol Biol. 2004 Dec;281(2):1227-33.
- Kern CB, Hoffman S, Moreno R, Damon BJ, Norris RA, Krug EL, Markwald RR, Mjaatvedt CH. Immunolocalization of chick periostin protein in the developing heart. Anat Rec A Discov Mol Cell Evol Biol. 2005 May;284(1):415-23.
- Mjaatvedt CH, Kern CB, Norris RA, Fairey S, Cave CL. Normal distribution of melanocytes in the mouse heart. Anat Rec A Discov Mol Cell Evol Biol. 2005 Aug;285(2):748-57.
- Norris RA, Kern CB, Wessels A, Wirrig EE, Markwald RR, Mjaatvedt CH. Detection of betaig-H3, a TGFbeta induced gene, during cardiac development and its complementary pattern with periostin. Anat Embryol (Berl). 2005 Aug;210(1):13-23. Epub 2005 Jul 21.