Chip Norris

Russell A. Norris, Ph.D.
Assistant Professor

Office: Room 608, Children's Research Institute, (843) 792-3544
Lab: Room 604F, Children's Research Institute, (843) 792-1544

Email: norrisra@musc.edu

For additional information about members of the Norris Lab


University of Cincinnati 1991-1995 Bachelors of Science (Biology)
Medical University of South Carolina 1995-2000 PhD (Molecular, Cellular and Pathobiology)
Medical University of South Carolina 2001-2006 Post Doctoral Research

Research Interests:

A primary focus of the Norris lab is to deal with basic questions in formation of the cardiac valves and pathological processes that result in valve disease. The overall design follows a “cycle of discovery” that begins with the clinical condition, identifies gene candidates, and explores their mechanism of action. These mechanistic studies, in turn, point to related pathways for further gene discovery. Through an international consortium of clinicians and scientists, our group has identified genetic and biological causes for common cardiac disease, e.g. mitral valve prolapse and bicuspid aortic valve disease. Our ongoing projects have defined that these genes play a crucial role during the development of the valves, essentially laying the blueprint for valve construction. Thus, inherited heart valve disease is caused by inborn errors in the development of this structure. By studying these disease genes we can gain an understanding for how the valve develops and why valve defects occur. Harnessed with this information, targeted therapeutics can be developed that may be of benefit to patients with valvular heart disease, thus allowing us to complete the “cycle of discovery”.


Recent Selected Publications:

  1. Sauls K, de Vlaming A, Harris BS, Williams K, Wessels A, Levine RA, Slaugenhaupt SA, Goodwin RL, Pavone LM, Merot J, Schott JJ, Le Tourneau T, Dix T, Jesinkey S, Feng Y, Walsh C, Zhou B, Baldwin S, Markwald RR, Norris RA. Developmental basis for filamin-A-associated myxomatous mitral valve disease.
    Cardiovasc Res. 2012 Oct 1;96(1):109-19
  2. Wessels A, van den Hoff MJ, Adamo RF, Phelps AL, Lockhart MM, Sauls K, Briggs LE, Norris RA, van Wijk B, Perez-Pomares JM, Dettman RW, Burch JB. Epicardially-derived fibroblasts preferentially contribute to the parietal leaflets of the atrioventricular valves in the murine heart.
    Dev Biol. 2012 Jun 15;366(2):111-24
  3. Doyle AJ, Doyle JJ, Bessling SL, Maragh S, Lindsay ME, Schepers D, Gillis E, Mortier G, Homfray T, Sauls K, Norris RA, Huso ND, Leahy D, Mohr DW, Caulfield MJ, Scott AF, Destrée A, Hennekam RC, Arn PH, Curry CC, Laer LV, McCallion AS, Loeys BL, Dietz HC. Mutations in the Prototypical TGF-β Repressor SKI Cause Shprintzen-Goldberg Syndrome with Aortic Aneurysm.
    Nature Genetics. 2012 Nov;44(11):1249-54
  4. Gallo EM, Loch DC, Habashi JP, Calderon JF, Chen Y, Bedja D, van Erp C, Gerber EE, Parker SJ, Sauls K, Judge DP, Cooke SK, Lindsay ME, Rouf R, Myers L, Ap Rhys CM, Kent KC, Norris RA, Huso DL, Dietz HC. Angiotensin II-dependent TGF-β signaling contributes to Loeys-Dietz syndrome vascular pathogenesis.
    J Clin Invest. 2014 Jan;124(1): 448-60.
  5. Ghatak S, Misra S, Norris RA, Moreno-Rodriguez RA, Hoffman S, Levine RA, Hascall VC, Markwald RR. Periostin induces intracellular cross-talk between kinases and hyaluronan in atrioventricular valvulogenesis.
    J Biol Chem. 2014 Mar 21;289(12):8545-61.
  6. Lockhart MM, Boukens BJ, Phelps AL, Brown CL, Toomer KA, Burns TA, Mukherjee RD, Norris RA, Trusk TC, van den Hoff MJ, Wessels A.  Alk3 mediated Bmp signaling controls the contribution of epicardially derived cells to the tissues of the atrioventricular junction.
    Dev Biol. 2014 Dec 1;396(1):8-18.
  7. Norris RA, on behalf of the Leducq Consortium for Valve Disease.  Non-syndromic mitral valve prolapse from gene mutations to modifiable mechanisms.
    Circulation. 2015; 130:A18977
  8. Durst R*, Sauls K*, Peal DS*, deVlaming A, Toomer K, Leyne M, Salani M, Talkowski ME, Harrison B, Perrocheau M, Simpson C, Jett C, Stone MR, Charles F, Chiang C, Lynch SN, Bouatia-Naji N, Delling FN, Freed LA, Tribouilloy C, LeTourneau T, LeMarec H, Fernandez-Friera L, Solis J, Trujillano D, Ossowski S, Estivill X, Dina C, Bruneval P, Chester A, Schott J-J, Irvine KD, Mao Y, Wessels A, Motiwala T, Puceat M, Tsukasaki Y, Menick DR, Kasiganesan H, Nie X, Broome A-M, Williams K, Johnson A, Markwald RR, Jeunemaitre X$, Hagege A$, Levine RA$, Milan DJ$, Norris RA$,#, Slaugenhaupt SA$,#. Mutations in DCHS1 Cause Mitral Valve Prolapse. *-Co-first authors with equal contribution, $-Co Senior Authors, #-Co-Corresponding authors
    Nature. 2015 Sep 3;525(7567):109-13. doi: 10.1038/nature14670.
  9. Dina C, Bouatia-Naji N, Tucker N, Delling FN, Toomer K, Durst R, Perrocheau M, Fernandez-Friera L, Solis J; PROMESA investigators, Le Tourneau T, Chen MH, Probst V, Bosse Y, Pibarot P, Zelenika D, Lathrop M, Hercberg S, Roussel R, Benjamin EJ, Bonnet F, Lo SH, Dolmatova E, Simonet F, Lecointe S, Kyndt F, Redon R, Le Marec H, Froguel P, Ellinor PT, Vasan RS, Bruneval P, Markwald RR, Norris RA*, Milan DJ*, Slaugenhaupt SA*, Levine RA*, Schott JJ*, Hagege AA*, Mvp-France, Jeunemaitre X*; Leducq Transatlantic MITRAL Network. *Co-Senior and co-corresponding authors with equal contribution. Genetic association analyses highlight biological pathways underlying mitral valve prolapse.
    Nature Genetics. 2015 Aug 24. doi: 10.1038/ng.3383
  10. Sauls K, Toomer K, Williams K, Johnson AJ, Markwald RR, Hajdu Z, Norris RA. Increased infiltration of extra-cardiac cells in Myxomatous valve disease.
    J. Cardiovasc. Dev. Dis. 2015, 2(3), 200-213
Last updated on 29-Oct-2015

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