Department of Regenerative Medicine and Cell biology

obrien

Terrence X. O'Brien, M.D.
Associate Professor


Room ART 7031
Office: (843) 876-4787

Email: obriente@musc.edu

Education:

BS Stanford
MS Stanford
MD University of California at San Diego

Research Interests:

Our laboratory has several specific interests, revolving around applying the tools of molecular biology to study transcriptional regulation in cellular and animal models of cardiac hypertrophy and failure.  Specific projects include examining the cardiac regulation of 2 oxidative phosphorylation genes whose products increase when cardiac myocytes hypertrophy.  Techniques include cell line and cardiac myocyte culture, models of hypertrophic stimulation as well as mouse and pulmonary artery banded cat models.  Additional effort is being put in an effort to use adenoviral vectors to allow transient transfection of adult cardiac myocytes.  Transcription factors being examined include the cardiac-specific homeobox factor Nkx2-5 as well as the more ubiquitous serum response transcription factor (SRF).  Molecular markers of abnormal cardiac hypertrophy as well as changes in protein synthesis and cellular morphogenesis are examed as end-points.  Cardiac physiologic studies in animal models include using echocardiography and invasive hemodynamics.

Recent Publications:

  1. Harris, B. S., C. F. Baicu, N. Haghshenas, H. Kasiganesan, D. Scholz, M. S. Rackley, L. Miquerol, D. Gros, R. Mukherjee and T. X. O'Brien. "Remodeling of the Peripheral Cardiac Conduction System in Response to Pressure Overload." Am J Physiol Heart Circ Physiol 302, no. 8 (2012): H1712-25 [PMID: 22307665]
  2. Moscariello, A., R. Vliegenthart, U. J. Schoepf, J. W. Nance, Jr., P. L. Zwerner, M. Meyer, J. C. Townsend, V. Fernandes, D. H. Steinberg, C. Fink, M. Oudkerk, L. Bonomo, T. X. O'Brien and T. Henzler. "Coronary Ct Angiography Versus Conventional Cardiac Angiography for Therapeutic Decision Making in Patients with High Likelihood of Coronary Artery Disease." Radiology 265, no. 2 (2012): 385-92 [PMID: 22875799]
  3. Brabham, W. W., G. F. Lewis, D. D. Bonnema, C. D. Nielsen and T. X. O'Brien. "Takotsubo Cardiomyopathy in a Patient with Previously Undiagnosed Hypertrophic Cardiomyopathy with Obstruction." Cardiovasc Revasc Med 12, no. 1 (2011): 70 e1-5 [PMID: 21036671]
  4. Moscariello, A., R. A. Takx, U. J. Schoepf, M. Renker, P. L. Zwerner, T. X. O'Brien, T. Allmendinger, S. Vogt, B. Schmidt, G. Savino, C. Fink, L. Bonomo and T. Henzler. "Coronary Ct Angiography: Image Quality, Diagnostic Accuracy, and Potential for Radiation Dose Reduction Using a Novel Iterative Image Reconstruction Technique-Comparison with Traditional Filtered Back Projection." Eur Radiol 21, no. 10 (2011): 2130-8 [PMID: 21611758]
  5. O'Brien, T. X. "Iron Metabolism, Anemia, and Heart Failure." J Am Coll Cardiol 58, no. 12 (2011): 1252-3 [PMID: 21903059]
  6. Renker, M., J. W. Nance, Jr., U. J. Schoepf, T. X. O'Brien, P. L. Zwerner, M. Meyer, J. M. Kerl, R. W. Bauer, C. Fink, T. J. Vogl and T. Henzler. "Evaluation of Heavily Calcified Vessels with Coronary Ct Angiography: Comparison of Iterative and Filtered Back Projection Image Reconstruction." Radiology 260, no. 2 (2011): 390-9 [PMID: 21693660]
  7. Bastarrika, G., W. W. Brabham, T. X. O'Brien, P. Costello and U. J. Schoepf. "Dual-Source Computed Tomography Assessment of Malfunctioning Mechanical Prosthetic Valve." Ann Thorac Surg 87, no. 5 (2009): e50 [PMID: 19379857]
  8. Colley, B. J., 3rd and T. X. O'Brien. "Cardiac Tamponade: Still Being Newly Described." South Med J 99, no. 1 (2006): 4 [PMID: 16466106]
  9. Harris, B. S., L. Spruill, A. M. Edmonson, M. S. Rackley, D. W. Benson, T. X. O'Brien and R. G. Gourdie. "Differentiation of Cardiac Purkinje Fibers Requires Precise Spatiotemporal Regulation of Nkx2-5 Expression." Dev Dyn 235, no. 1 (2006): 38-49 [PMID: 16245335]
  10. Mitchell, G. F., J. M. Arnold, M. E. Dunlap, T. X. O'Brien, G. Marchiori, E. Warner, C. B. Granger, S. S. Desai and M. A. Pfeffer. "Pulsatile Hemodynamic Effects of Candesartan in Patients with Chronic Heart Failure: The Charm Program." Eur J Heart Fail 8, no. 2 (2006): 191-7 [PMID: 16188495]
  11. Harris, B. S., R. G. Gourdie and T. X. O'Brien. "Atrioventricular Conduction System and Transcription Factors Nkx2.5 and Msx2." J Cardiovasc Electrophysiol 16, no. 1 (2005): 86-7 [PMID: 15673395]
  12. Little, W. C., M. R. Zile, D. W. Kitzman, W. G. Hundley, T. X. O'Brien and R. C. Degroof. "The Effect of Alagebrium Chloride (Alt-711), a Novel Glucose Cross-Link Breaker, in the Treatment of Elderly Patients with Diastolic Heart Failure." J Card Fail 11, no. 3 (2005): 191-5 [PMID: 15812746]
  13. Harris, B. S., P. Y. Jay, M. S. Rackley, S. Izumo, O'Brien T. X. and R. G. Gourdie. "Transcriptional Regulation of Cardiac Conduction System Development: 2004 Faseb Cardiac Conduction System Minimeeting, Washington, Dc." Anat Rec A Discov Mol Cell Evol Biol 280, no. 2 (2004): 1036-45 [PMID: 15368344]
  14. Jay, P. Y., B. S. Harris, A. Buerger, O. Rozhitskaya, C. T. Maguire, L. A. Barbosky, E. McCusty, C. I. Berul, O'Brien T. X., R. G. Gourdie and S. Izumo. "Function Follows Form: Cardiac Conduction System Defects in Nkx2-5 Mutation." Anat Rec A Discov Mol Cell Evol Biol 280, no. 2 (2004): 966-72 [PMID: 15368343]
  15. Jay, P. Y., B. S. Harris, C. T. Maguire, A. Buerger, H. Wakimoto, M. Tanaka, S. Kupershmidt, D. M. Roden, T. M. Schultheiss, T. X. O'Brien, R. G. Gourdie, C. I. Berul and S. Izumo. "Nkx2-5 Mutation Causes Anatomic Hypoplasia of the Cardiac Conduction System." J Clin Invest 113, no. 8 (2004): 1130-7 [PMID: 15085192]

 

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