Department of Regenerative Medicine and Cell biology

reeves

Titus A. Reaves, Ph.D.
Assistant Professor



Room 619, Basic Science Building
Office: (843) 792-9372
Lab: (843) 792-1087

Email: reaves@musc.edu

Education:

PhD, Univ. of South Carolina School of Medicine, 1998
Postdoctoral Fellow, Emory University

Research Interests:

My research interests involve epithelial cell biology and neutrophil (PMN) migration. PMN migration is the immune systems first line of defense against infection serving as a major component of the acute innate inflammatory response. When an inflammatory response is initiated at the epithelium, PMN must exit the bloodstream; traverse the endothelium, the lamina propria, and the tight junction to finally reach the lumenal side of epithelium. Thus, PMN transepithelial migration is a multi-step receptor mediated process. PMN transmigration is also common in a number of inflammatory diseases of the gastrointestinal system (ulcerative colitis, Crohn's disease, bacterial enterocolitis), hepatobiliary system (cholangitis, acute cholecystitis), urinary tract (pyelonephritis, cystitis), respiratory tract (bronchial pneumonia, bronchitis, cystic fibrosis) and others. The primary goal of my research is to understand the molecular events that regulate PMN migration and how the epithelium interacts with PMN to facilitate such migration.

Recent Publications:

  1. Chin, A. C., B. Fournier, E. J. Peatman, T. A. Reaves, W. Y. Lee and C. A. Parkos. "Cd47 and Tlr-2 Cross-Talk Regulates Neutrophil Transmigration." J Immunol 183, no. 9 (2009): 5957-63 [PMID: 19812191]
  2. Zen, K., T. A. Reaves, I. Soto and Y. Liu. "Response to Genistein: Assaying the Activation Status and Chemotaxis Efficacy of Isolated Neutrophils." J Immunol Methods 309, no. 1-2 (2006): 86-98 [PMID: 16412456]
  3. Reaves, T. A., A. C. Chin and C. A. Parkos. "Neutrophil Transepithelial Migration: Role of Toll-Like Receptors in Mucosal Inflammation." Mem Inst Oswaldo Cruz 100 Suppl 1, (2005): 191-8 [PMID: 15962122]
  4. Edens, H. A., B. P. Levi, D. L. Jaye, S. Walsh, T. A. Reaves, J. R. Turner, A. Nusrat and C. A. Parkos. "Neutrophil Transepithelial Migration: Evidence for Sequential, Contact-Dependent Signaling Events and Enhanced Paracellular Permeability Independent of Transjunctional Migration." J Immunol 169, no. 1 (2002): 476-86 [PMID: 12077279]
  5. Reaves, T. A., S. P. Colgan, P. Selvaraj, M. M. Pochet, S. Walsh, A. Nusrat, T. W. Liang, J. L. Madara and C. A. Parkos. "Neutrophil Transepithelial Migration: Regulation at the Apical Epithelial Surface by Fc-Mediated Events." Am J Physiol Gastrointest Liver Physiol 280, no. 4 (2001): G746-54 [PMID: 11254502]
  6. Liu, Y., A. Nusrat, F. J. Schnell, T. A. Reaves, S. Walsh, M. Pochet and C. A. Parkos. "Human Junction Adhesion Molecule Regulates Tight Junction Resealing in Epithelia." J Cell Sci 113 ( Pt 13), (2000): 2363-74 [PMID: 10852816]

 

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