Department of Regenerative Medicine and Cell Biology


Yukiko Sugi , D.V.M., Ph.D.
Associate Professor

Room 635, Basic Science Building
Office: (843) 792-6501
Lab: (843) 792-4603



DVM Veterinary Medicine Yamaguchi University 1977
MS Veterinary Science Yamaguchi University 1979
PhD Cell Biology Saitama Medical School 1986

Research Interests:

Tissue interaction and determination in early heart development. Cardiac valve formation. Growth Factors

Recent Publications:

  1. Inai K, Burnside JL, Hoffman S, Toole BP & Sugi Y. BMP-2 induces versican and hyaluronan that contribute to post-EMT AV cushion cell migration. PLoS One 2013 8: e77593 [PMID: 24147033].
  2. Sugi, Y*., Kern, M. J., Markwald, R. R. and Burnside, J. L. Periostin expression is altered in aortic valves in Smad6 mutant mice. J. Neonatal Biol. 1: 101, 2012.
  3. Little TS, Mironov V, Nagy Mehesz A, Markwald R, Sugi Y, Lessner SM, Sutton MA, Liu X, Wang Q, Yang X, Blancette JO & Skiles M. Engineering a 3D, biological construct: representative research in the South Carolina Project for Organ Biofabrication. Biofabrication 2011 3: 030202 [PMID: 21926458].
  4. Norris RA, Moreno-Rodriguez RA, Sugi Y, Hoffman S, Amos J, Hart MM, Potts JD, Goodwin RL & Markwald RR. Periostin regulates atrioventricular valve maturation. Dev Biol 2008 316: 200-213 [PMID: 18313657].
  5. Inai K, Norris RA, Hoffman S, Markwald RR & Sugi Y. BMP-2 induces cell migration and periostin expression during atrioventricular valvulogenesis. Dev Biol 2008 315: 383-396 [PMID: 18261719].
  6. Okagawa H, Markwald RR & Sugi Y. Functional BMP receptor in endocardial cells is required in atrioventricular cushion mesenchymal cell formation in chick. Dev Biol 2007 306: 179-192 [PMID: 17449024].
  7. Norris RA, Damon B, Mironov V, Kasyanov V, Ramamurthi A, Moreno-Rodriguez R, Trusk T, Potts JD, Goodwin RL, Davis J, Hoffman S, Wen X, Sugi Y, Kern CB, Mjaatvedt CH, Turner DK, Oka T, Conway SJ, Molkentin JD, Forgacs G & Markwald RR. Periostin regulates collagen fibrillogenesis and the biomechanical properties of connective tissues. J Cell Biochem 2007 101: 695-711 [PMID: 17226767].
  8. Sugi Y, Yamamura H, Okagawa H & Markwald RR. Bone morphogenetic protein-2 can mediate myocardial regulation of atrioventricular cushion mesenchymal cell formation in mice. Dev Biol 2004 269: 505-518 [PMID: 15110716].
  9. Sugi Y & Markwald RR. Endodermal growth factors promote endocardial precursor cell formation from precardiac mesoderm. Dev Biol 2003 263: 35-49 [PMID: 14568545].
  10. Sugi Y, Ito N, Szebenyi G, Myers K, Fallon JF, Mikawa T & Markwald RR. Fibroblast growth factor (FGF)-4 can induce proliferation of cardiac cushion mesenchymal cells during early valve leaflet formation. Dev Biol 2003 258: 252-263 [PMID: 12798286].
  11. Twal WO, Czirok A, Hegedus B, Knaak C, Chintalapudi MR, Okagawa H, Sugi Y & Argraves WS. Fibulin-1 suppression of fibronectin-regulated cell adhesion and motility. J Cell Sci 2001 114: 4587-4598 [PMID: 11792823].
  12. Sugi Y & Markwald RR. Early endocardial formation originates from precardiac mesoderm as revealed by QH-1 antibody staining. Ital J Anat Embryol 1995 100 Suppl 1: 263-272 [PMID: 11322300].
  13. Lough J & Sugi Y. Endoderm and heart development. Dev Dyn 2000 217: 327-342 [PMID: 10767078].
  14. Ramsdell AF, Moreno-Rodriguez RA, Wienecke MM, Sugi Y, Turner DK, Mjaatvedt CH & Markwald RR. Identification of an autocrine signaling pathway that amplifies induction of endocardial cushion tissue in the avian heart. Acta Anat (Basel) 1998 162: 1-15 [PMID: 9789103].
  15. Markwald R, Eisenberg C, Eisenberg L, Trusk T & Sugi Y. Epithelial-mesenchymal transformations in early avian heart development. Acta Anat (Basel) 1996 156: 173-186 [PMID: 9124035].
  16. Lough J, Barron M, Brogley M, Sugi Y, Bolender DL & Zhu X. Combined BMP-2 and FGF-4, but neither factor alone, induces cardiogenesis in non-precardiac embryonic mesoderm. Dev Biol 1996 178: 198-202 [PMID: 8812122].
  17. Sugi Y & Markwald RR. Formation and early morphogenesis of endocardial endothelial precursor cells and the role of endoderm. Dev Biol 1996 175: 66-83 [PMID: 8608870].
  18. Sugi Y, Sasse J & Lough J. Inhibition of precardiac mesoderm cell proliferation by antisense oligodeoxynucleotide complementary to fibroblast growth factor-2 (FGF-2). Dev Biol 1993 157: 28-37 [PMID: 8482417].
  19. Sugi Y & Lough J. Anterior endoderm is a specific effector of terminal cardiac myocyte differentiation of cells from the embryonic heart forming region. Dev Dyn 1994 200: 155-162 [PMID: 7919501].
  20. Byeon MK, Sugi Y, Markwald RR & Hoffman S. NCAM polypeptides in heart development: association with Z discs of forms that contain the muscle-specific domain. J Cell Biol 1995 128: 209-221 [PMID: 7822416].
  21. Sugi Y, Sasse J, Barron M & Lough J. Developmental expression of fibroblast growth factor receptor-1 (cek-1; flg) during heart development. Dev Dyn 1995 202: 115-125 [PMID: 7734730].
  22. Sugi Y & Lough J. Activin-A and FGF-2 mimic the inductive effects of anterior endoderm on terminal cardiac myogenesis in vitro. Dev Biol 1995 168: 567-574 [PMID: 7729588].
  23. Makita T, Hatsuoka M & Sugi Y. Calcium detection in secretion granules of avian oviduct by scanning electron microscopy (SEM) and energy-dispersive X-ray microanalysis (EDX). J Histochem Cytochem 1983 31: 219-221 [PMID: 6827073].
  24. Gotoh T, Sugi Y & Hirakow R. Ultrastructural construction of collagen fibrils as revealed by the freeze-fracture technique. J Electron Microsc (Tokyo) 1983 32: 213-215 [PMID: 6672159].
  25. Sugi Y & Hirakow R. Freeze-fracture studies of the sinoatrial and atrioventricular nodes of the caprine heart, with special reference to the nexus. Cell Tissue Res 1986 245: 273-279 [PMID: 3742562].
  26. Sugi Y & Hirakow R. Ultrastructural quantitative characterisation of sinus and atrioventricular nodal cells in the developing caprine heart compared with ordinary atrial and ventricular myocardial cells. J Anat 1986 148: 13-24 [PMID: 3693082].
  27. Sugi Y. Visualization and identification of cytoskeletal filaments in embryonic chick heart by the quick-freeze deep-etch method combined with immunocytochemistry. J Electron Microsc (Tokyo) 1989 38: 126-131 [PMID: 2769143].
  28. Gotoh T & Sugi Y. Electron-microscopic study of the collagen fibrils of the rat tail tendon as revealed by freeze-fracture and freeze-etching techniques. Cell Tissue Res 1985 240: 529-534 [PMID: 2410127].
  29. Sugi Y & Hirakow R. Cytoskeletal filaments in embryonic chick myocardial cells as revealed by the quick-freeze deep-etch method combined with immunocytochemistry. Cell Tissue Res 1991 263: 459-469 [PMID: 1878933].
  30. Sugi Y & Lough J. Onset of expression and regional deposition of alpha-smooth and sarcomeric actin during avian heart development. Dev Dyn 1992 193: 116-124 [PMID: 1581600].
Last updated on 27-Aug-2015

© 2015  Medical University of South Carolina | Disclaimer