Department of Regenerative Medicine and Cell biology

Research in Focus

Toll-like Receptor 6 Regulation of Intestinal Fibrosis

A major complication of Crohn's Disease is intestinal fibrosis resulting from an over-production of collagen by intestinal fibroblasts. Investigators in the laboratory of Dr. Titus Reaves have found that fibroblasts exposed to interleukin-6 (IL-6), an inflammatory cytokine abundant in Crohn's Disease, display reduced expression of toll-like receptor 6 (TLR-6) and matrix metalloproteinase-2 (MMP-2), a collagen degrading protease. Furthermore, they found that siRNA-mediated suppression of TLR-6 in fibroblasts leads to reduced expression of MMP-2 and augmented expression of both collagen and CD36, a collagen receptor. The findings highlight TLR-6 as a potential mediator of intestinal fibrosis and a therapeutic target. rif2

posted 9/28/2011

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